Find en hypertensionsforsker

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Odense

Jane Stubbe

2

Hospitalsenheden Vest:

Jesper Nørgaard Bech, professor

Nikolai Hoffmann-Petersen, PhD

Bodil Gade Hornstrup, PhD

3

Aarhus

Niels Henrik Buus, professor

Mark Reinhart, PhD

4

Holbæk Sygehus

Professor Michael Hecht Olsen

5

Region hovedstaden

Ali Asmar

Dansk hypertensionsforskning

Titel på publikationNocturnal blood pressure in patients with chronic kidney disease, in patients with hypertension and in healthy controls – the influence of obstructive sleep apnoea and renal function.
NavnBodil Gade Hornstrup
Årstal for publikation2019
Måned for publikationFebruar
Navn på hovedforfatterBodil Gade Hornstrup
Format
  • PhD-afhandling
Type af forskning
  • Klinisk forskning
Abstract/ summary

Blood pressure decrease from day to night is a common phenomenon in healthy human. In some humans, this normal regulation is disturbed which leads to a lack of nocturnal blood pressure decrease. High blood pressure, especially lack of nocturnal blood pressure decrease, is important as risk factor for cardiovascular disease and death. The risk increases with blood pressure level. The presence of obstructive sleep apnea is also associated with increased risk of cardiovascular disease and high blood pressure.

Lack of blood pressure decrease at night is seen especially in patients with impaired renal function. This patient population also have an increased incidence of obstructive sleep apnoea. It is unclear how these conditions (renal function and obstructive sleep apnoea) affect nocturnal blood pressure decrease.

Therefore, the aim of the studies in this PhD project was to investigate the correlation between the nocturnal blood pressure (and 24 hour blood pressure) measured by different methods, the degree of renal function impairment and the incidence of obstructive sleep apnoea in patients with impaired renal function, in patients with high blood pressure, and in healthy controls. In addition, an intervention study was conducted in which patients diagnosed with moderate to severe obstructive sleep apnoea were offered CPAP treatment to investigate the effect of treatment of obstructive sleep apnoea on blood pressure.

The results showed that there was an increased incidence of high nocturnal blood pressure and obstructive sleep apnoea in patients with impaired renal function. The increased incidence of high nocturnal blood pressure and obstructive sleep apnoea could best be explained by classic lifestyle factors and risk factors and not by the degree of renal function impairment. CPAP treatment had a beneficial effect on blood pressure.

AfdelingUniversity Clinic in Nephrology and Hypertension, HEV
UniversitetAarhus University

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Hypertensionsartikler i Ugeskrift For Læger
Temanumre 24 og 25 år 2009

Hans Ibsens pris for fremme af hypertensionsforskning i Danmark

Tidligere modtagere:

2008, Emil Toft Brøndum

2010, overlæge i pædiatri, ph.d. og klinisk ekstern og forskningslektor, Jens-Christian Holm​

2013, dr. med., professor og overlæge Erling Bjerregaard Pedersen, se link.

2020